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Surprising Side Effects of Taking CBD Supplements, Says Science

Here are four mild symptoms you may experience when taking cannabidiol.
FACT CHECKED BY Kiersten Hickman

CBD, which stands for cannabidiol, has been shown to provide several health benefits to the body and mind, including stress relief, alleviation of chronic pain, and may even help those with epilepsy manage seizures. It may even treat acne, anxiety, drug addiction, and high blood pressure.

As is the case with any supplement, you could also experience some side effects, especially if you're new to CBD. Thankfully, the most common side effects of taking CBD are minor, but still be sure to clear it with your physician before taking the supplement (in any form) as it could interfere with a medication you're currently taking.

Now, here are four possible side effects you could experience from taking CBD. Then, be sure to read our list of The 7 Healthiest Foods to Eat Right Now.


womany sleepy leaning on coffee table

One of CBD's many benefits is that it can make you feel relaxed, but at the same time, it can also cause you to feel drowsy or fatigued, per the Mayo Clinic. While this is a mild symptom, it's definitely one to keep in mind, especially when it comes to deciding what time of day to take your dose of CBD. Consider taking it before you go to bed or after work, that way you're on your A-game when you need to be.

According to the Sleep Foundation, preliminary research has shown that taking CBD before bed may improve sleep, especially for those who have sleep disorders including insomnia, REM sleep behavior disorder, and excessive daytime sleepiness disorder.

Gastrointestinal issues

cbd oil bottle next to marijuana leaf

One of the most common side effects of CBD (along with other cannabinoids as a whole) is reduced appetite, which could result in weight loss. However, one downside to taking CBD is that it can also cause some GI distress, including diarrhea. But that could be a result of taking too high of a dose. In fact, some CBD oils are actually recommended to take to help reduce bouts of diarrhea.


Kelly Sikkema/ Unsplash

Some people may become nauseous after taking a CBD supplement, which may also be a result of taking too much. Those who are extra sensitive to CBD may also be at higher risk of experiencing nausea after taking an oil, tincture, capsule, or CBD-infused food item.

Again, it's important to note that the supplement could also quell symptoms of nausea. Preclinical research has indicated that cannabinoids such as CBD may be effective at treating nausea and vomiting in those who are undergoing chemotherapy or other intensive treatments.

Dry mouth

Woman Taking CBD Oil Under Tongue

Another mild side effect you may experience after taking a CBD supplement is dry mouth. The likelihood of getting a dry or "cotton" mouth is much higher when taking a CBD supplement that's also infused with THC. However, CBD may also contribute to this symptom on its own. A small 2006 study on rats showed that both cannabinoids (which include THC and CBD) can play a role in inhibiting saliva production. To avoid this, hydrate regularly and consider chewing on some gum.

For more, be sure to check out the 5 Best New CBD Products to Add to Your Diet.

Cheyenne Buckingham
Cheyenne Buckingham is the former news editor of Eat This, Not That! Read more about Cheyenne